Fabricio Prado Monteiro
Medical Director, Institute of Allergy and Immunology of West Bahia, Brazil
Biography:
Fabrício Prado Monteiro has his expertise and passion in evaluating and improving the health and immunology. He is a Medical Director at Institute of Allergy and Immunology of West Bahia, Brazil & Specialist in Allergology & Immunology (since 2006, by ASBAI). He is a Specialist in Pediatrics (since 2004, by SBP), has masters (UCES/ARG) in Administration and Economics (Management) in Health (public and private). He has built work model after years of experience in research, evaluation, teaching and attention in pediatrics and clinical allergy and immunology, both in hospital and education instructions
Abstract:
IgM is the first immunoglobulin to be expressed on the surface of B cells and the first immunoglobulin isotype secreted during an initial immune response to an exogenous antigen. Mature naïve B cells in response to antigens undergo clonal expansion and differentiation into Ig-secreting cells. A subset of activated IgM+ B cells undergo a process of heavy chain isotype switching resulting in the production of antibodies of different isotypes such as IgG, IgA, and IgE, upon engagement of CD40 with CD40L and interaction with cytokines, and somatic hyper mutation in V region results in the selection of high affinity antibody producing B cells (1,2).
In contrast to secreted IgG, IgM comes in two flavors, pre-immune or without exposure to exogenous antigen also known as “natural IgM” that is spontaneously produced, and the second type is exogenous antigen-induced or “immune” IgM antibodies. In addition to providing early defense against microbes, natural IgM plays an important role in immune homeostasis, and provide protection from consequences of infections and inflammation (1,3).
Beyond its well-known effects on calcium homeostasis and bone mineralization, vit.D has become recognized as a pluripotent immunoregulator of biological functions with a particular role in immune tolerance and antimicrobial immunity. The expression of the vit.D receptor (VDR) in many immune cells have led to recognition of the associations between the vit.D metabolism and infections, allergic and cronic auto immune disorders (4,5,6).
Immunostimulating subcutaneous therapy as proposed, according to protocol and subcutaneous and muscular administration bimonthly of glucan and glucoronidase (ITA BG ®) associated with VIT.D 600.000 UI (HERVA’S PINEDA PHARMACIAS ®) , providing an increase of antigenic recognition because of an efficient activation of antigen presenting cells through up-regulation of their receivers. (7,8).
Thus the activation and degranulation of inflammatory products that cause various clinical manifestations are minimized and regulated, with the consequent clinical improvement and no adverse effects.